A decade of genome-wide association studies for coronary artery disease: the challenges ahead

Cardiovasc Res. 2018 Jul 15;114(9):1241-1257. doi: 10.1093/cvr/cvy084.


In this review, we summarize current knowledge on the genetics of coronary artery disease, based on 10 years of genome-wide association studies. The discoveries began with individual studies using 200K single nucleotide polymorphism arrays and progressed to large-scale collaborative efforts, involving more than a 100 000 people and up to 40 Mio genetic variants. We discuss the challenges ahead, including those involved in identifying causal genes and deciphering the links between risk variants and disease pathology. We also describe novel insights into disease biology based on the findings of genome-wide association studies. Moreover, we discuss the potential for discovery of novel treatment targets through the integration of different layers of 'omics' data and the application of systems genetics approaches. Finally, we provide a brief outlook on the potential for precision medicine to be enhanced by genome-wide association study findings in the cardiovascular field.

Publication types

  • Historical Article
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Coronary Artery Disease / diagnosis
  • Coronary Artery Disease / genetics*
  • Coronary Artery Disease / history
  • Coronary Artery Disease / therapy
  • Diffusion of Innovation
  • Forecasting
  • Genetic Markers*
  • Genetic Predisposition to Disease
  • Genetic Variation*
  • Genome-Wide Association Study* / history
  • Genome-Wide Association Study* / trends
  • Heredity
  • History, 21st Century
  • Humans
  • Pedigree
  • Phenotype
  • Precision Medicine* / history
  • Precision Medicine* / trends
  • Predictive Value of Tests
  • Prognosis
  • Risk Factors


  • Genetic Markers