LncRNAs regulate the cytoskeleton and related Rho/ROCK signaling in cancer metastasis

Yanyan Tang; Yi He; Ping Zhang; Jinpeng Wang; Chunmei Fan; Liting Yang; Fang Xiong; Shanshan Zhang; Zhaojian Gong; Shaolin Nie; Qianjin Liao; Xiayu Li; Xiaoling Li; Yong Li; Guiyuan Li; Zhaoyang Zeng; Wei Xiong; Can Guo

doi:10.1186/s12943-018-0825-x

LncRNAs regulate the cytoskeleton and related Rho/ROCK signaling in cancer metastasis

Mol Cancer. 2018 Apr 4;17(1):77. doi: 10.1186/s12943-018-0825-x.

Authors

Yanyan Tang^{1

2}, Yi He^{1

2}, Ping Zhang^{2

3}, Jinpeng Wang², Chunmei Fan², Liting Yang², Fang Xiong⁴, Shanshan Zhang^{2

5}, Zhaojian Gong², Shaolin Nie¹, Qianjin Liao^{1

2}, Xiayu Li^{2

6}, Xiaoling Li^{2

5}, Yong Li⁴, Guiyuan Li^{1

2

5}, Zhaoyang Zeng^{1

2

5}, Wei Xiong^{7

8

9}, Can Guo^{10

11

12}

Affiliations

¹ Department of Colorectal Surgery, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China.
² The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, Hunan, China.
³ School of Electronics and Information Engineering, Hunan University of Science and Engineering, Yongzhou, Hunan, China.
⁴ Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.
⁵ The Key Laboratory of Carcinogenesis of the Chinese Ministry of Health, Xiangya Hospital, Central South University, Changsha, Hunan, China.
⁶ Hunan Key Laboratory of Nonresolving Inflammation and Cancer, Disease Genome Research Center, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
⁷ Department of Colorectal Surgery, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China. xiongwei@csu.edu.cn.
⁸ The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, Hunan, China. xiongwei@csu.edu.cn.
⁹ The Key Laboratory of Carcinogenesis of the Chinese Ministry of Health, Xiangya Hospital, Central South University, Changsha, Hunan, China. xiongwei@csu.edu.cn.
¹⁰ Department of Colorectal Surgery, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China. guocde@csu.edu.cn.
¹¹ The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, Hunan, China. guocde@csu.edu.cn.
¹² The Key Laboratory of Carcinogenesis of the Chinese Ministry of Health, Xiangya Hospital, Central South University, Changsha, Hunan, China. guocde@csu.edu.cn.

Abstract

Some of the key steps in cancer metastasis are the migration and invasion of tumor cells; these processes require rearrangement of the cytoskeleton. Actin filaments, microtubules, and intermediate filaments involved in the formation of cytoskeletal structures, such as stress fibers and pseudopodia, promote the invasion and metastasis of tumor cells. Therefore, it is important to explore the mechanisms underlying cytoskeletal regulation. The ras homolog family (Rho) and Rho-associated coiled-coil containing protein serine/threonine kinase (ROCK) signaling pathway is involved in the regulation of the cytoskeleton. Moreover, long noncoding RNAs (lncRNAs) have essential roles in tumor migration and guide gene regulation during cancer progression. LncRNAs can regulate the cytoskeleton directly or may influence the cytoskeleton via Rho/ROCK signaling during tumor migration. In this review, we focus on the regulatory association between lncRNAs and the cytoskeleton and discuss the pathways and mechanisms involved in the regulation of cancer metastasis.

Keywords: Cancer metastasis; Cytoskeleton; Long noncoding RNA; Rho/ROCK signaling.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Cytoskeleton / genetics
Cytoskeleton / metabolism*
Disease Progression
Humans
Neoplasm Metastasis / genetics*
RNA, Long Noncoding / genetics*
Signal Transduction
rho GTP-Binding Proteins / metabolism
rho-Associated Kinases / metabolism

Substances

RNA, Long Noncoding
rho-Associated Kinases
rho GTP-Binding Proteins