Susceptibility of Diabetic Mice to Noise Trauma

Biomed Res Int. 2018 Feb 12;2018:7601232. doi: 10.1155/2018/7601232. eCollection 2018.


Diabetes can lead to many end-organ complications. However, the association between diabetes and hearing loss is not well understood. Here, we investigated the effect of noise exposure on diabetic mice compared with wild-type mice. Hearing threshold shifts, histopathologic changes in the cochlea, and inflammatory responses were evaluated over time. After noise exposure, more severe hearing threshold shifts, auditory hair cell loss, and synaptopathies were notable in diabetic mice compared with wild-type mice. Moreover, increased inflammatory responses and reactive oxygen species production were observed in the ears of diabetic mice. The results demonstrated that diabetic mice are more susceptible to noise trauma.

MeSH terms

  • Animals
  • Auditory Threshold
  • Cell Count
  • Cell Survival
  • Cytokines / metabolism
  • Diabetes Mellitus, Experimental / complications*
  • Diabetes Mellitus, Experimental / physiopathology
  • Disease Susceptibility
  • Epithelium / pathology
  • Epithelium / physiopathology
  • Evoked Potentials, Auditory, Brain Stem
  • Hair Cells, Auditory, Outer / pathology
  • Inflammation Mediators / metabolism
  • Mice, Inbred C57BL
  • Noise / adverse effects*
  • Oxidative Stress
  • Reactive Oxygen Species / metabolism
  • Synapses / pathology
  • Wounds and Injuries / complications*
  • Wounds and Injuries / physiopathology


  • Cytokines
  • Inflammation Mediators
  • Reactive Oxygen Species