Systemic mastocytosis identified in two women developing fragility fractures during lactation

Osteoporos Int. 2018 Jul;29(7):1671-1674. doi: 10.1007/s00198-018-4498-5. Epub 2018 Apr 4.


Two women presenting with fragility fractures during lactation had bone mineral density (BMD) reduced more greatly than usually associated with lactation. The first woman was 29 years old with a BMD T-score of - 3.2 SD at the spine and- 2.0 SD at the femoral neck. The second woman was 35 years old with a BMD T-score of - 4.5 SD at the spine and - 2.8 SD at the femoral neck. Both women had increased cortical porosity and reduced trabecular density. Investigation identified an elevated serum tryptase, and marrow biopsy confirmed the diagnosis of mastocytosis. Lactation causes bone loss, but the occurrence of fractures in the setting of severe deficits in BMD and microstructural deterioration signals the need to consider additional causes of bone loss.

Keywords: Bone loss; Fractures; Lactation; Mastocytosis; Osteoporosis.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Bone Density / physiology
  • Female
  • Femur Neck / physiopathology
  • Humans
  • Lactation / physiology*
  • Lumbar Vertebrae / physiopathology
  • Mastocytosis, Systemic / complications*
  • Osteoporotic Fractures / etiology*
  • Osteoporotic Fractures / physiopathology
  • Spinal Fractures / etiology
  • Spinal Fractures / physiopathology