T-cell receptor delta gene rearrangements in early thymocytes

Nature. 1987 Dec 24-31;330(6150):722-7. doi: 10.1038/330722a0.

Abstract

The T-cell receptor delta-chain variable region can be assembled from as many as four distinct gene segments, V, D1, D2 and J, more than any other antigen-receptor gene. In fetal thymocytes V----D joinings are as common as D----J or VDJ rearrangements and one V gene segment predominates. Analysis of rearrangements at TCR gamma and delta loci during fetal ontogeny suggests abrupt changes and possible coordinate control in the rearrangement and expression of these loci.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Age Factors
  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Fetus / physiology
  • Genes
  • Mice
  • Molecular Sequence Data
  • Receptors, Antigen, T-Cell / genetics*
  • Receptors, Antigen, T-Cell, gamma-delta
  • T-Lymphocytes / physiology*
  • Thymus Gland / cytology
  • Thymus Gland / embryology

Substances

  • Receptors, Antigen, T-Cell
  • Receptors, Antigen, T-Cell, gamma-delta