Hydrophilic interaction chromatography in food matrices analysis: An updated review

Food Chem. 2018 Aug 15:257:53-66. doi: 10.1016/j.foodchem.2018.03.008. Epub 2018 Mar 2.


This review focuses on the most recent papers (from 2011 to submission date in 2017) dealing with the analysis of different organic components in foods (i.e. nucleobases, nucleosides, nucleotides, uric acid, and creatinine, amino acids and related compounds, choline-related compounds and phospholipids, carbohydrates, artificial sweeteners and polyphenolic compounds), using hydrophilic interaction liquid chromatography (HILIC) combined with different detection techniques. For each compound class, the investigated food matrices are grouped per: foods of animal origin, vegetables, fruits and related products, baby food, and other matrices such as drinks and mushrooms/fungi. Furthermore, the main advantages of HILIC chromatography respect to the other commonly used techniques are discussed.

Keywords: Food analysis; HILIC; Review; Stationary phases.

Publication types

  • Review

MeSH terms

  • Animals
  • Chromatography, Liquid / methods*
  • Food Analysis / methods*
  • Humans
  • Hydrophobic and Hydrophilic Interactions*