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The Association of Tau With Mitochondrial Dysfunction in Alzheimer's Disease


The Association of Tau With Mitochondrial Dysfunction in Alzheimer's Disease

Ying Cheng et al. Front Neurosci.


Increasing evidence suggests that abnormally hyperphosphorylated tau plays a vital role in the pathogenesis of Alzheimer's disease (AD). Mitochondrial dysfunction also has a recognized role in the pathophysiology of AD. In recent years, mitochondrial dysfunction has been strongly associated with tau pathology in AD. Overexpression of hyperphosphorylated and aggregated tau appears to damage the axonal transport, leading to abnormal mitochondrial distribution. In addition, pathological tau impairs mitochondrial dynamics by regulating mitochondrial fission/fusion proteins, and further causes mitochondrial dysfunction and neuronal damage. Moreover, mitochondrial dysfunction is also involved in promoting tau pathology in AD. In this article, we evaluate the relationship between phosphorylated tau and mitochondrial dysfunction in AD.

Keywords: Alzheimer's disease; mitochondrial dynamics; mitochondrial dysfunction; mitochondrial transport; tau.

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    1. Amos L. A. (2004). Microtubule structure and its stabilisation. Org. Biomol. Chem. 2, 2153–2160. 10.1039/b403634d - DOI - PubMed
    1. Arnold C. S., Johnson G. V., Cole R. N., Dong D. L., Lee M., Hart G. W. (1996). The microtubule-associated protein tau is extensively modified with O-linked N-acetylglucosamine. J. Biol. Chem. 271, 28741–28744. 10.1074/jbc.271.46.28741 - DOI - PubMed
    1. Atlante A., Amadoro G., Bobba A., De Bari L., Corsetti V., Pappalardo G., et al. . (2008). A peptide containing residues 26–44 of tau protein impairs mitochondrial oxidative phosphorylation acting at the level of the adenine nucleotide translocator. Biochim. Biophys. Acta 1777, 1289–1300. 10.1016/j.bbabio.2008.07.004 - DOI - PubMed
    1. Ballatore C., Lee V. M., Trojanowski J. Q. (2007). Tau-mediated neurodegeneration in Alzheimer's disease and related disorders. Nat. Rev. Neurosci. 8, 663–672. 10.1038/nrn2194 - DOI - PubMed
    1. Binder L. I., Frankfurter A., Rebhun L. I. (1985). The distribution of tau in the mammalian central nervous system. J. Cell Biol. 101, 1371–1378. 10.1083/jcb.101.4.1371 - DOI - PMC - PubMed

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