Sinergism between alkaloids piperine and capsaicin with meglumine antimoniate against Leishmania infantum

Exp Parasitol. 2018 May;188:79-82. doi: 10.1016/j.exppara.2018.04.001. Epub 2018 Apr 3.

Abstract

The primary choice of drugs to treat Leishmaniasis are the pentavalent antimony-based compounds, nevertheless these drugs presented undesirable side effects. However, safe natural compounds could be used in combination with these drugs to enhance their activity. The aim of this study was to evaluate the sinergism of capsaicin and piperine, isolated from Capsicum frutescens and Piper nigrum, respectively, in combination with meglumine antimoniate against Leishmania infantum promastigote and amastigote forms. Each compound was mixed with the standard drug in several percentage mixtures and tested at various concentrations. Capsaicin and piperine in combination with meglumine antimoniate (25% + 75%) showed better anti-leishmanial activity with EC50 = 4.31 ± 0.44 e 7.25 ± 4.84 μg/mL against promastigote and amastigote forms, respectively. The results point that these spice alkaloids are suitable compounds to be administered in combinations with antileishmanial drugs to improve their action.

Keywords: Anti-leishmanial; Capsaicine; Meglumine antimoniate; Piperine.

MeSH terms

  • Alkaloids / pharmacology*
  • Alkaloids / therapeutic use
  • Antiprotozoal Agents / pharmacology*
  • Antiprotozoal Agents / therapeutic use
  • Benzodioxoles / pharmacology*
  • Benzodioxoles / therapeutic use
  • Capsaicin / pharmacology*
  • Capsaicin / therapeutic use
  • Chromatography, High Pressure Liquid
  • Drug Synergism
  • Inhibitory Concentration 50
  • Leishmania infantum / drug effects*
  • Leishmaniasis, Visceral / drug therapy
  • Magnetic Resonance Spectroscopy
  • Meglumine / pharmacology*
  • Meglumine / therapeutic use
  • Meglumine Antimoniate
  • Organometallic Compounds / pharmacology*
  • Organometallic Compounds / therapeutic use
  • Piperidines / pharmacology*
  • Piperidines / therapeutic use
  • Polyunsaturated Alkamides / pharmacology*
  • Polyunsaturated Alkamides / therapeutic use
  • Spectrophotometry, Ultraviolet

Substances

  • Alkaloids
  • Antiprotozoal Agents
  • Benzodioxoles
  • Organometallic Compounds
  • Piperidines
  • Polyunsaturated Alkamides
  • Meglumine
  • Meglumine Antimoniate
  • Capsaicin
  • piperine