The current landscape of nucleic acid tests for filovirus detection

J Clin Virol. 2018 Jun;103:27-36. doi: 10.1016/j.jcv.2018.03.005. Epub 2018 Mar 22.

Abstract

Nucleic acid testing (NAT) for pathogenic filoviruses plays a key role in surveillance and to control the spread of infection. As they share clinical features with other pathogens, the initial spread of these viruses can be misdiagnosed. Tests that can identify a pathogen in the initial stages of infection are essential to control outbreaks. Since the Ebola virus disease (EVD) outbreak in 2014-2016 several tests have been developed that are faster than previous tests and more suited for field use. Furthermore, the ability to test for a range of pathogens simultaneously has been expanded to improve clinical pathway management of febrile syndromes. This review provides an overview of these novel diagnostic tests.

Keywords: Diagnostics; Ebola; Filoviridae; Marburg; NAT; Point-of-care.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Filoviridae / isolation & purification*
  • Filoviridae Infections / diagnosis*
  • Humans
  • Molecular Diagnostic Techniques / methods*
  • RNA, Viral / genetics
  • RNA, Viral / isolation & purification*

Substances

  • RNA, Viral