Dietary astaxanthin can accumulate in the brain of rats

Yuki Manabe; Toshiyuki Komatsu; Shinobu Seki; Tatsuya Sugawara

doi:10.1080/09168451.2018.1459467

Dietary astaxanthin can accumulate in the brain of rats

Biosci Biotechnol Biochem. 2018 Aug;82(8):1433-1436. doi: 10.1080/09168451.2018.1459467. Epub 2018 Apr 6.

Authors

Yuki Manabe¹, Toshiyuki Komatsu¹, Shinobu Seki², Tatsuya Sugawara¹

Affiliations

¹ a Graduate School of Agriculture , Kyoto University , Kyoto , Japan.
² b Pharmaceutical and Healthcare Research Laboratories, Research and Development Management Headquarters , FUJIFILM Corporation , Kanagawa , Japan.

PMID: 29625535
DOI: 10.1080/09168451.2018.1459467

Abstract

We evaluated the distribution of astaxanthin in rat brains after a single dose administration and after feeding 0.1% astaxanthin diet for 5 days. Astaxanthin was detected in the hippocampus and cerebral cortex 4 and 8 h after a single dose. Astaxanthin concentration in rat brains was higher after consumption of astaxanthin diet for 5 days than after a single dose.

Keywords: Astaxanthin; absorption; brain; cerebral cortex; hippocampus.

MeSH terms

Animals
Antioxidants / administration & dosage
Antioxidants / metabolism*
Antioxidants / pharmacology
Cerebral Cortex / metabolism*
Diet*
Hippocampus / metabolism*
Male
Oxidative Stress / drug effects
Rats, Sprague-Dawley
Xanthophylls / administration & dosage
Xanthophylls / blood
Xanthophylls / metabolism
Xanthophylls / pharmacology

Substances

Antioxidants
Xanthophylls
astaxanthine