Clinical and biologic characterization of T-cell neoplasias with rearrangements of chromosome 7 band q34

Blood. 1988 Feb;71(2):395-402.

Abstract

In T cell malignancy, rearrangements of chromosome 14 have been observed with a break in the band that contains the alpha chain gene for the T cell receptor (TCR). Because the beta chain TCR gene is in chromosome band 7q34, we searched for and report finding specific rearrangements of 7q34 exclusively in T cell malignancies. The rearrangements were reciprocal translocations between 7q34 and other points: 1p34, 9q32, 9q34, 15q22, and 19p13. The malignancies containing a 7q34 translocation were either T cell acute lymphoblastic leukemias or T cell lymphoblastic lymphomas that had similarities in clinical, enzyme, immunologic, and cellular characteristics. Hybridization using a probe to the beta-TCR gene disclosed unique rearrangements consistent with clonality in every case. A common pattern with chromosome breakpoints involving TCR genes may be emerging in T cell neoplasia.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adenosine Deaminase / metabolism
  • Antibodies, Monoclonal
  • Antigens, Differentiation, T-Lymphocyte / analysis
  • Antigens, Neoplasm / analysis
  • Antigens, Surface / analysis
  • Chromosome Aberrations / physiopathology*
  • Chromosome Banding
  • Chromosome Disorders
  • Chromosomes, Human, Pair 7*
  • Humans
  • Leukemia, Lymphoid / genetics*
  • Purine-Nucleoside Phosphorylase / metabolism
  • Receptors, Antigen, T-Cell / genetics
  • Receptors, Antigen, T-Cell, alpha-beta
  • Translocation, Genetic*
  • Tumor Cells, Cultured

Substances

  • Antibodies, Monoclonal
  • Antigens, Differentiation, T-Lymphocyte
  • Antigens, Neoplasm
  • Antigens, Surface
  • Receptors, Antigen, T-Cell
  • Receptors, Antigen, T-Cell, alpha-beta
  • Purine-Nucleoside Phosphorylase
  • Adenosine Deaminase