Altered Cellular Metabolism Drives Trained Immunity

Trends Endocrinol Metab. 2018 Sep;29(9):602-605. doi: 10.1016/j.tem.2018.03.012. Epub 2018 Apr 5.


Exposing innate immune cells to an initial insult induces a long-term proinflammatory response due to metabolic and epigenetic alterations which encompass an emerging new concept called trained immunity. Recent studies provide novel insights into mechanisms centered on metabolic reprogramming which induce innate immune memory in hematopoietic stem cells and monocytes.

Keywords: HSPCs; epigenetics; immunometabolism; monocytes/macrophages; trained immunity.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Epigenesis, Genetic / immunology*
  • Hematopoietic Stem Cells / metabolism*
  • Humans
  • Immunity, Innate / immunology*
  • Monocytes / metabolism*