Associations of hemoglobin biomarker levels of acrylamide and all-cause and cardiovascular disease mortality among U.S. adults: National Health and Nutrition Examination Survey 2003-2006

Mengmeng Huang; Jingjing Jiao; Jun Wang; Xinyu Chen; Yu Zhang

doi:10.1016/j.envpol.2018.03.109

Associations of hemoglobin biomarker levels of acrylamide and all-cause and cardiovascular disease mortality among U.S. adults: National Health and Nutrition Examination Survey 2003-2006

Environ Pollut. 2018 Jul:238:852-858. doi: 10.1016/j.envpol.2018.03.109. Epub 2018 Apr 6.

Authors

Mengmeng Huang¹, Jingjing Jiao², Jun Wang¹, Xinyu Chen¹, Yu Zhang³

Affiliations

¹ National Engineering Laboratory of Intelligent Food Technology and Equipment, Zhejiang Key Laboratory for Agro-Food Processing, Fuli Institute of Food Science, College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou, Zhejiang, China.
² Department of Nutrition and Food Hygiene, School of Public Health, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
³ National Engineering Laboratory of Intelligent Food Technology and Equipment, Zhejiang Key Laboratory for Agro-Food Processing, Fuli Institute of Food Science, College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou, Zhejiang, China. Electronic address: y_zhang@zju.edu.cn.

PMID: 29627755
DOI: 10.1016/j.envpol.2018.03.109

Abstract

Background: The potential hazards of acrylamide (AA) have been proposed due to its lifelong exposure. However, the association between AA exposure and mortality remains unclear.

Objectives: We evaluated the prospective association of AA hemoglobin adducts (HbAA and HbGA) with all-cause and cardiovascular disease (CVD) mortality in U.S. population from National Health and Nutrition Examination Survey (NHANES) 2003-2006.

Methods: We followed 5504 participants who were ≥25 years of age for an average of 6.7 years at the baseline examination with annual linkage to the NHANES statistics database. Using AA hemoglobin biomarkers [HbAA, HbGA, sum of HbAA and HbGA (HbAA + HbGA), and ratio of HbGA to HbAA (HbGA/HbAA)], we determined mortality from all-causes and CVD through Cox proportional hazard regression analysis with multivariable adjustments both in non-smoker group and smoker group. In addition, subgroup analyses and sensitivity analyses were further conducted.

Results: After adjusting for sociodemographic, life behavioral and cardiovascular risk factors in non-smoker group, HbAA was positively associated with all-cause mortality (p for trend = 0.0197) and non-CVD mortality (p for trend = 0.0124). HbGA and HbGA/HbAA were inversely associated with all-cause mortality (p for trend = 0.0117 and 0.0098, respectively) and CVD mortality (p for trend=0.0009 and 0.0036, respectively). The multivariable adjusted hazard ratios (HRs) [95% confidence intervals (CIs)] of the upper three quartiles were 0.472 (95% CI: 0.283-0.786), 0.517 (95% CI: 0.299-0.894) and 0.470 (95% CI: 0.288-0.766) between HbGA/HbAA and all-cause mortality comparing with the lowest quartile, respectively. No significant associations were found between HbAA + HbGA and mortality in non-smoker group, and between all AA hemoglobin biomarkers and mortality in smoker group.

Conclusions: Hemoglobin biomarker levels of AA were strongly associated with mortality in general U.S. non-smoker adults. These findings proposed a continuous public health concern in relation to environmental and dietary exposure to AA.

Keywords: Acrylamide; Cardiovascular disease; Hemoglobin biomarkers; Mortality; NHANES.

MeSH terms

Acrylamide / metabolism*
Acrylamide / toxicity
Adult
Aged
Biomarkers
Cardiovascular Diseases / metabolism
Cardiovascular Diseases / mortality*
Environmental Exposure / statistics & numerical data*
Epoxy Compounds
Female
Hemoglobin A
Hemoglobins / metabolism*
Humans
Male
Middle Aged
Nutrition Surveys
Prospective Studies
Regression Analysis
United States / epidemiology

Substances

Biomarkers
Epoxy Compounds
Hemoglobins
Acrylamide
hemoglobin AA
Hemoglobin A