Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
, 39 (6), 536-546

Macrophage-Targeted Therapeutics for Metabolic Disease

Affiliations
Review

Macrophage-Targeted Therapeutics for Metabolic Disease

Kristin R Peterson et al. Trends Pharmacol Sci.

Abstract

Macrophages are cells of the innate immune system that are resident in all tissues, including metabolic organs such as the liver and adipose tissue (AT). Because of their phenotypic flexibility, they play beneficial roles in tissue homeostasis, but they also contribute to the progression of metabolic disease. Thus, they are ideal therapeutic targets for diseases such as insulin resistance (IR), nonalcoholic fatty liver disease (NAFLD), and atherosclerosis. Recently, discoveries in the area of drug delivery have facilitated phenotype-specific targeting of macrophages. In this review we discuss advances in potential therapeutics for metabolic diseases via macrophage-specific delivery. We highlight micro- and nanoparticles, liposomes, and oligopeptide complexes, and how they can be used to alter macrophage phenotype for a more metabolically favorable tissue environment.

Keywords: liposome; macrophage; metabolic disease; nanoparticle; obesity; therapeutics.

Similar articles

See all similar articles

Cited by 13 articles

See all "Cited by" articles

MeSH terms

Substances

Feedback