LKB1: Controlling Quiescence and Genomic Integrity at Home

Carmen Berasain; Matías A Ávila

doi:10.1016/j.tem.2018.03.017

LKB1: Controlling Quiescence and Genomic Integrity at Home

Trends Endocrinol Metab. 2018 Oct;29(10):668-670. doi: 10.1016/j.tem.2018.03.017. Epub 2018 Apr 5.

Authors

Carmen Berasain¹, Matías A Ávila²

Affiliations

¹ Hepatology Program, Cima-University of Navarra, Pamplona, Spain; Centro de Investigación Biomédica en Red, Enfermedades Hepáticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, Madrid, Spain; Instituto de Investigaciones Sanitarias de Navarra (IDISNA), Pamplona, Spain. Electronic address: cberasain@unav.es.
² Hepatology Program, Cima-University of Navarra, Pamplona, Spain; Centro de Investigación Biomédica en Red, Enfermedades Hepáticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, Madrid, Spain; Instituto de Investigaciones Sanitarias de Navarra (IDISNA), Pamplona, Spain.

PMID: 29628399
DOI: 10.1016/j.tem.2018.03.017

Abstract

The pleiotropic liver kinase B1 (LKB1) controls metabolism, cell polarity, and proliferation in an apparently cell- and context-specific manner. A recent study in Cell Reports has demonstrated that LKB1 is essential to maintain the characteristic quiescence of the liver and to secure genomic integrity during liver regeneration independently of AMPK.

Keywords: EGFR; LKB1; genome stability; hepatocyte quiescence; liver regeneration; mitosis fidelity.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Cell Proliferation
Genomics
Hepatocytes
Liver Regeneration*
Organogenesis*