Review: Management of patients with kidney allograft failure

Transplant Rev (Orlando). 2018 Jul;32(3):178-186. doi: 10.1016/j.trre.2018.03.001. Epub 2018 Mar 29.

Abstract

Late allograft loss in kidney transplant recipients remains a common problem and is associated with high mortality and morbidity. The management of patients with a failed kidney allograft includes a few major dilemmas: when to start dialysis, what is the optimal management regarding immunosuppression, and should an allograft nephrectomy be performed. In suitable candidates for a repeated transplantation there are additional matters to take in consideration. In this review we will discuss these dilemmas by providing an overview of current evidence and gaps in our knowledge. As many of these issues are incompletely resolved, we conclude that more studies are needed to improve the management of patients with a failed kidney allograft.

Publication types

  • Review

MeSH terms

  • Allografts
  • Graft Rejection / diagnosis
  • Graft Rejection / etiology
  • Graft Rejection / therapy*
  • Humans
  • Immunosuppressive Agents / therapeutic use
  • Kidney Transplantation / adverse effects*
  • Nephrectomy
  • Renal Dialysis
  • Renal Insufficiency / diagnosis
  • Renal Insufficiency / etiology
  • Renal Insufficiency / therapy*

Substances

  • Immunosuppressive Agents