Association of sleep disturbances with obesity, insulin resistance and the metabolic syndrome

Metabolism. 2018 Jul:84:67-75. doi: 10.1016/j.metabol.2018.04.001. Epub 2018 Apr 6.


Insufficient sleep, which has become endemic in recent years, has been variably associated with increased risk of obesity, disorders of glucose and insulin homeostasis, and the metabolic syndrome; to a lesser degree, so has excessive sleep. This review summarizes recent epidemiological and pathophysiological evidence linking sleep disturbances (primarily abnormalities of sleep duration) with obesity, insulin resistance, type 2 diabetes and the metabolic syndrome in children and adults.

Keywords: Insulin resistance; Metabolic syndrome; Obesity; Sleep.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Adult
  • Child
  • Humans
  • Insulin Resistance / physiology*
  • Metabolic Syndrome / complications
  • Metabolic Syndrome / epidemiology*
  • Metabolic Syndrome / metabolism
  • Obesity / complications
  • Obesity / epidemiology*
  • Obesity / metabolism
  • Sleep / physiology
  • Sleep Wake Disorders / complications
  • Sleep Wake Disorders / epidemiology*
  • Sleep Wake Disorders / metabolism