Fat soluble vitamin levels in children with newly diagnosed celiac disease, a case control study

BMC Pediatr. 2018 Apr 9;18(1):130. doi: 10.1186/s12887-018-1107-x.


Background: In children diagnosed with celiac disease, fat soluble vitamin levels were aimed to be evaluated and it was intended to determine whether fat soluble vitamin levels were needed to be assessed routinely in these patients during diagnosis.

Methods: Between May 2015-May 2016, diagnosis symptoms of celiac patients (CD) in newly diagnosed pediatric group were questioned, fat soluble vitamin levels simultaneous with intestinal biopsies were evaluated. Vitamin levels were compared with those of healthy control group.

Results: A total of 52 patients involving 27 female (51.9%), 25 male (48.1%); and a total of 50 healthy control group including 25 female (50%), 25 male (50%) were evaluated. The average age of patients was 9 ± 4.3 years, and their average weight was determined as 16.2 ± 6.3 kg. Growth retardation was the most frequent symptom in our patients (61.5%). Abdominal pain (51.9%) and diarrhea (11.5%) are among the other most commonly seen symptoms. In the histological examination of patients, Marsh 3B n = 23 (45.1%) was mostly established. Vitamin A and vitamin D levels of patients were determined significantly lower compared to those of control group. Vitamin A and vitamin D deficiencies were identified significantly higher compared to those of healthy control group. Vitamin D insufficiency was observed in 48 patients (92.3%) and vitamin D deficiency was determined in 32 (61.5%) out of 48. Vitamin A deficiency was established in 17 (32.7%) patients. Vitamin E and vitamin K1 deficiency were determined in no patients. In the healthy control group, vitamin D deficiency was seen in 2 (4%) patients, vitamin D insufficiency was determined in 9 (18%) patients. Other vitamin levels were identified at normal levels in the healthy group.

Conclusions: In newly diagnosed children with CD, a significant lowness was established in vitamin D and A. The evaluation of vitamin A and D levels will be helpful in the course of diagnosis in these patients.

Keywords: Celiac disease; Children; Fat-soluble vitamins.

MeSH terms

  • Adolescent
  • Avitaminosis / etiology*
  • Case-Control Studies
  • Celiac Disease / blood
  • Celiac Disease / complications*
  • Celiac Disease / diagnosis*
  • Celiac Disease / pathology
  • Child
  • Child, Preschool
  • Female
  • Humans
  • Infant
  • Infant, Newborn
  • Intestines / pathology
  • Male
  • Vitamin A Deficiency / etiology
  • Vitamin D Deficiency / etiology
  • Vitamin E Deficiency / etiology
  • Vitamin K 1 / blood
  • Vitamin K Deficiency / etiology


  • Vitamin K 1