Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2018 May;19(5):453-463.
doi: 10.1038/s41590-018-0082-6. Epub 2018 Apr 9.

Peptide-specific Recognition of Human Cytomegalovirus Strains Controls Adaptive Natural Killer Cells

Affiliations

Peptide-specific Recognition of Human Cytomegalovirus Strains Controls Adaptive Natural Killer Cells

Quirin Hammer et al. Nat Immunol. .

Abstract

Natural killer (NK) cells are innate lymphocytes that lack antigen-specific rearranged receptors, a hallmark of adaptive lymphocytes. In some people infected with human cytomegalovirus (HCMV), an NK cell subset expressing the activating receptor NKG2C undergoes clonal-like expansion that partially resembles anti-viral adaptive responses. However, the viral ligand that drives the activation and differentiation of adaptive NKG2C+ NK cells has remained unclear. Here we found that adaptive NKG2C+ NK cells differentially recognized distinct HCMV strains encoding variable UL40 peptides that, in combination with pro-inflammatory signals, controlled the population expansion and differentiation of adaptive NKG2C+ NK cells. Thus, we propose that polymorphic HCMV peptides contribute to shaping of the heterogeneity of adaptive NKG2C+ NK cell populations among HCMV-seropositive people.

Comment in

  • Adaptive responses of innate lymphocytes.
    Watzl C. Watzl C. Nat Immunol. 2018 May;19(5):426-427. doi: 10.1038/s41590-018-0088-0. Nat Immunol. 2018. PMID: 29670228 No abstract available.
  • Specificity for HCMV strains.
    Minton K. Minton K. Nat Rev Immunol. 2018 Jun;18(6):358-359. doi: 10.1038/s41577-018-0010-x. Nat Rev Immunol. 2018. PMID: 29674650 No abstract available.

Similar articles

See all similar articles

Cited by 51 articles

See all "Cited by" articles

Publication types

MeSH terms

Substances

LinkOut - more resources

Feedback