The role of diallyl thiosulfinate associated with nuciferine and diosgenin in the treatment of premature ejaculation: A pilot study

Arch Ital Urol Androl. 2018 Mar 31;90(1):59-64. doi: 10.4081/aiua.2018.1.59.


Objective: To assess the efficacy and safety of an association of diallyl thiosulfinate with nuciferine and diosgenin in the treatment of a group of patients suffering from premature ejaculation (PE), primary or secondary to erectile dysfunction (ED).

Materials and methods: From July 2015 to October 2016, 143 patients (mean age 25.3; range 18-39) affected by PE completed the study and were finally analyzed in this phase I study. All patients, after clinical assessment and laboratory evaluation were asked to take an association of diallyl thiosulfinate with nuciferine and diosgenin as oral tablet, once a day, on alternate days, for three months. At the baseline and after three months of treatment, each patient was asked to complete the following questionnaires: International Index of Erectile Function (IIEF-5), Premature Ejaculation Diagnostic Tool (PEDT), Male Sexual Health Questionnaire (MSHQ).

Results: A statistical significant improvement in terms of erectile function, comparing the IIEF-5 value at baseline and follow- up visit was found (respectively IIEF-5: 8.7 vs 14.01; p < 0.001). Moreover, at follow-up visit, 97/143 men (67.8%) referred a subjective improvement of the erection quality and a better control of the ejaculation (PROs). The IELT improved too between the baseline evaluation and the follow-up visit (p < 0.001).

Conclusion: In conclusion, our study, even if supported by preliminary results, showed how Diallyl Thiosulfinate, Nuciferine and Diosgenin is able to improve the control of ejaculation in patients suffering from PE, primary or secondary to ED without any significant adverse effects.

Keywords: Diosgenin; Muciferine; Plant extracts; Premature ejaculation; Thiosulfinate; Treatment.

Publication types

  • Clinical Trial, Phase I

MeSH terms

  • Adolescent
  • Adult
  • Aporphines / adverse effects
  • Aporphines / therapeutic use*
  • Diosgenin / adverse effects
  • Diosgenin / therapeutic use*
  • Disulfides
  • Drug Therapy, Combination
  • Erectile Dysfunction / drug therapy
  • Humans
  • Male
  • Penile Erection
  • Pilot Projects
  • Premature Ejaculation / drug therapy*
  • Sexual Health
  • Sulfinic Acids / adverse effects
  • Sulfinic Acids / therapeutic use*
  • Treatment Outcome
  • Young Adult


  • Aporphines
  • Disulfides
  • Sulfinic Acids
  • allicin
  • Diosgenin
  • nuciferine