Adipocyte p62/SQSTM1 Suppresses Tumorigenesis through Opposite Regulations of Metabolism in Adipose Tissue and Tumor

Cancer Cell. 2018 Apr 9;33(4):770-784.e6. doi: 10.1016/j.ccell.2018.03.001.

Abstract

Obesity is a leading risk factor for cancer. However, understanding the crosstalk between adipocytes and tumor cells in vivo, independently of dietary contributions, is a major gap in the field. Here we used a prostate cancer (PCa) mouse model in which the signaling adaptor p62/Sqstm1 is selectively inactivated in adipocytes. p62 loss in adipocytes results in increased osteopontin secretion, which mediates tumor fatty acid oxidation and invasion, leading to aggressive metastatic PCa in vivo. Furthermore, p62 deficiency triggers in adipocytes a general shutdown of energy-utilizing pathways through mTORC1 inhibition, which supports nutrient availability for cancer cells. This reveals a central role of adipocyte's p62 in the symbiotic adipose tissue-tumor collaboration that enables cancer metabolic fitness.

Keywords: CPT1; adipocyte; cancer; fatty acid oxidation; metabolic reprogramming; obesity; osteopontin; p62; prostate; sequestosome-1.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Adipose Tissue / metabolism
  • Animals
  • Carnitine O-Palmitoyltransferase / metabolism
  • Cell Line, Tumor
  • Cell Transformation, Neoplastic / metabolism*
  • Energy Metabolism
  • Fatty Acids / metabolism
  • Humans
  • Male
  • Mice
  • Neoplasm Transplantation
  • Obesity / complications*
  • Obesity / genetics
  • Obesity / metabolism
  • Osteopontin / metabolism*
  • Prognosis
  • Prostatic Neoplasms / genetics
  • Prostatic Neoplasms / metabolism*
  • Sequestosome-1 Protein / genetics*
  • Sequestosome-1 Protein / metabolism*

Substances

  • Fatty Acids
  • SPP1 protein, human
  • SQSTM1 protein, human
  • Sequestosome-1 Protein
  • Osteopontin
  • CPT1A protein, human
  • Carnitine O-Palmitoyltransferase