Effect of Withania somnifera on glycosaminoglycan synthesis in carrageenin-induced air pouch granuloma

Biochem Med Metab Biol. 1987 Dec;38(3):272-7. doi: 10.1016/0885-4505(87)90091-0.


The effect of W. somnifera on glycosaminoglycan synthesis in the granulation tissue of carrageenin-induced air pouch granuloma was studied. W. somnifera was shown to exert significant inhibitory effect on incorporation of 35S into the granulation tissue. The uncoupling effect on oxidative phosphorylation (ADP/O ratio reduction) was also observed in the mitochondria of granulation tissue. Further, Mg2+ dependent ATPase activity was found to be influenced by W. somnifera. W. somnifera also reduced the succinate dehydrogenase enzyme activity in the mitochondria of granulation tissue.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenosine Triphosphatases / metabolism
  • Animals
  • Blood Cell Count
  • Carrageenan
  • Glycosaminoglycans / biosynthesis*
  • Granuloma / chemically induced
  • Granuloma / metabolism*
  • Hydrocortisone / pharmacology
  • Male
  • Phenylbutazone / pharmacology
  • Plant Extracts / pharmacology*
  • Rats
  • Rats, Inbred Strains
  • Sulfates / metabolism
  • Sulfur Radioisotopes
  • Uncoupling Agents


  • Glycosaminoglycans
  • Plant Extracts
  • Sulfates
  • Sulfur Radioisotopes
  • Uncoupling Agents
  • Carrageenan
  • Adenosine Triphosphatases
  • Phenylbutazone
  • Hydrocortisone