Vitamin D supplementation in adolescents with irritable bowel syndrome: Is it useful? A randomized controlled trial

Saudi J Gastroenterol. 2018 Mar-Apr;24(2):109-114. doi: 10.4103/sjg.SJG_438_17.


Background/aim: Vitamin D deficiency is common in irritable bowel syndrome (IBS). There is growing interest in the role of vitamin D in pediatric IBS. We aimed to evaluate the effect of vitamin D supplementation in adolescents with IBS and vitamin D deficiency.

Patients and methods: One hundred and twelve adolescents with IBS and vitamin D deficiency were randomly divided into two groups of matched age and sex. The first group received oral vitamin D3 2000IU/day for 6 months and the second group received placebo for 6 months. Vitamin D status as well as different IBS score systems (IBS-SSS, IBS-QoL, and total score) were evaluated before and 6 months after treatment.

Results: IBS patients who received vitamin D supplementation for 6 months showed significant improvement in IBS-SSS (P < 0.001), IBS-QoL (P < 0.001), and total score (P = 0.02) compared to IBS placebo group. IBS patients treated with vitamin D showed two folds increase in their serum vitamin D levels (from 17.2 ± 1.3 to 39 ± 3.3) ng/ml with P < 0.001. While in the placebo group, their serum vitamin D levels were not significantly changed (P = 0.66). Vitamin D was tolerated well without any recorded adverse effects during the study period.

Conclusion: Vitamin D supplementation can be effective in treating adolescents with IBS and vitamin D deficiency.

Keywords: Adolescents; irritable bowel syndrome; vitamin D.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Administration, Oral
  • Adolescent
  • Dietary Supplements
  • Female
  • Humans
  • Irritable Bowel Syndrome / drug therapy*
  • Male
  • Prospective Studies
  • Treatment Outcome
  • Vitamin D / administration & dosage*
  • Vitamin D / therapeutic use
  • Vitamin D Deficiency / drug therapy*


  • Vitamin D