Hidden Peptides Encoded by Putative Noncoding RNAs

Cell Struct Funct. 2018 May 18;43(1):75-83. doi: 10.1247/csf.18005. Epub 2018 Apr 11.

Abstract

Although the definition of a noncoding RNA (ncRNA) is an RNA molecule that does not encode a protein, recent evidence has revealed that some ncRNAs are indeed translated to give rise to small polypeptides (usually containing fewer than 100 amino acids). Despite their small size, however, these peptides are often biologically relevant in that they are required for a variety of cellular processes. In this review, we summarize the production and functions of peptides that have been recently identified as translation products of putative ncRNAs.Key words: long noncoding RNA (lncRNA), circular RNA (circRNA), primary miRNA (pri-miRNA), translation, peptide.

Keywords: circular RNA (circRNA); long noncoding RNA (lncRNA); peptide; primary miRNA (pri-miRNA); translation.

Publication types

  • Review

MeSH terms

  • Animals
  • Drosophila Proteins / genetics
  • Drosophila Proteins / metabolism
  • MicroRNAs / metabolism
  • Peptide Hormones / genetics
  • Peptide Hormones / metabolism
  • Peptides / genetics
  • Peptides / metabolism*
  • Positive Transcriptional Elongation Factor B / genetics
  • Positive Transcriptional Elongation Factor B / metabolism
  • RNA / metabolism
  • RNA, Circular
  • RNA, Long Noncoding / metabolism
  • RNA, Untranslated / metabolism*

Substances

  • Drosophila Proteins
  • MicroRNAs
  • Peptide Hormones
  • Peptides
  • RNA, Circular
  • RNA, Long Noncoding
  • RNA, Untranslated
  • pgc protein, Drosophila
  • RNA
  • Positive Transcriptional Elongation Factor B