We propose a prospective motion correction approach for background suppressed (BS) segmented 3D GRASE pCASL using volumetric EPI-based navigators (vNavs), which causes minimal contrast change and no extra time. vNavs reduced motion artifacts effectively and increased temporal signal-to-noise ratio (t-SNR). Principle component analysis (PCA) is able to further reduce residual motion artifacts and restore the details of gyral structure in perfusion weighted images..