Abstract
5-HT induced a hyperpolarization of the rat superior cervical ganglion in vitro which was resistant to both MDL 72222 (10 microM), a 5-HT3 antagonist, and ketanserin (1 microM), a 5-HT2 antagonist. The 5-HT1-selective ligands 5-carboxamidotryptamine and 8-OH-DPAT also hyperpolarized the ganglion. The 5-HT-induced hyperpolarization was potently antagonised by spiperone. These results suggest that 5-HT hyperpolarizes the rat superior cervical ganglion via a 5-HT1-like receptor which resembles the central 5-HT1A binding site.
MeSH terms
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8-Hydroxy-2-(di-n-propylamino)tetralin
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Animals
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Ganglia, Sympathetic / drug effects
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Ganglia, Sympathetic / physiology*
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In Vitro Techniques
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Ketanserin / pharmacology
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Membrane Potentials / drug effects
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Rats
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Receptors, Serotonin / drug effects
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Receptors, Serotonin / physiology*
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Serotonin / analogs & derivatives
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Serotonin / pharmacology
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Serotonin Antagonists / pharmacology
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Tetrahydronaphthalenes / pharmacology
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Tropanes / pharmacology
Substances
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Receptors, Serotonin
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Serotonin Antagonists
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Tetrahydronaphthalenes
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Tropanes
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Serotonin
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8-Hydroxy-2-(di-n-propylamino)tetralin
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5-carboxamidotryptamine
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Ketanserin
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bemesetron