A 5-HT1-like receptor mediates a sympathetic ganglionic hyperpolarization

Eur J Pharmacol. 1987 Dec 15;144(3):385-8. doi: 10.1016/0014-2999(87)90393-1.

Abstract

5-HT induced a hyperpolarization of the rat superior cervical ganglion in vitro which was resistant to both MDL 72222 (10 microM), a 5-HT3 antagonist, and ketanserin (1 microM), a 5-HT2 antagonist. The 5-HT1-selective ligands 5-carboxamidotryptamine and 8-OH-DPAT also hyperpolarized the ganglion. The 5-HT-induced hyperpolarization was potently antagonised by spiperone. These results suggest that 5-HT hyperpolarizes the rat superior cervical ganglion via a 5-HT1-like receptor which resembles the central 5-HT1A binding site.

MeSH terms

  • 8-Hydroxy-2-(di-n-propylamino)tetralin
  • Animals
  • Ganglia, Sympathetic / drug effects
  • Ganglia, Sympathetic / physiology*
  • In Vitro Techniques
  • Ketanserin / pharmacology
  • Membrane Potentials / drug effects
  • Rats
  • Receptors, Serotonin / drug effects
  • Receptors, Serotonin / physiology*
  • Serotonin / analogs & derivatives
  • Serotonin / pharmacology
  • Serotonin Antagonists / pharmacology
  • Tetrahydronaphthalenes / pharmacology
  • Tropanes / pharmacology

Substances

  • Receptors, Serotonin
  • Serotonin Antagonists
  • Tetrahydronaphthalenes
  • Tropanes
  • Serotonin
  • 8-Hydroxy-2-(di-n-propylamino)tetralin
  • 5-carboxamidotryptamine
  • Ketanserin
  • bemesetron