Cytosolic Uptake of Large Monofunctionalized Dextrans

Bioconjug Chem. 2018 Jun 20;29(6):1942-1949. doi: 10.1021/acs.bioconjchem.8b00198. Epub 2018 Apr 25.


Dextrans are a versatile class of polysaccharides with applications that span medicine, cell biology, food science, and consumer goods. Here, we report on a new type of large monofunctionalized dextran that exhibits unusual properties: efficient cytosolic and nuclear uptake. This dextran permeates various human cell types without the use of transfection agents, electroporation, or membrane perturbation. Cellular uptake occurs primarily through active transport via receptor-mediated processes. These monofunctionalized dextrans could serve as intracellular delivery platforms for drugs or other cargos.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Biological Transport
  • Cell Line
  • Cell Nucleus / metabolism
  • Cytosol / metabolism*
  • Dextrans / chemistry*
  • Dextrans / pharmacokinetics*
  • Drug Carriers / chemistry*
  • Drug Carriers / pharmacokinetics*
  • HeLa Cells
  • Humans
  • Models, Molecular


  • Dextrans
  • Drug Carriers