Are Cushing's disease patients curable?

Ann Endocrinol (Paris). 2018 Jun;79(3):153-156. doi: 10.1016/j.ando.2018.03.012. Epub 2018 Apr 9.

Abstract

Treatment of Cushing's disease remains a challenge. Whereas pituitary surgery can "cure" the patient and restore a completely normal pituitary adrenal axis, there are immediate failures and late recurrences which ultimately require alternate therapeutic approaches. These are numerous, but so are their drawbacks, and all appear to be "default options". For the future, pituitary adenoma has to remain the "reasonable obsession" of efficient and optimistic therapists….

Keywords: Chirurgie surrénalienne; Cushing's disease; Fonction hypophyso-surrénalienne; Maladie de Cushing; Pituitary adrenal axis; Pituitary surgery.

Publication types

  • Review

MeSH terms

  • Adenoma / metabolism
  • Adenoma / physiopathology
  • Adenoma / therapy
  • Adrenalectomy / methods
  • Adrenalectomy / standards
  • Adrenocorticotropic Hormone / metabolism
  • Humans
  • Hydrocortisone / metabolism
  • Hypothalamo-Hypophyseal System / physiopathology
  • Pituitary ACTH Hypersecretion / epidemiology
  • Pituitary ACTH Hypersecretion / physiopathology
  • Pituitary ACTH Hypersecretion / therapy*
  • Pituitary Neoplasms / metabolism
  • Pituitary Neoplasms / physiopathology
  • Pituitary Neoplasms / therapy
  • Pituitary-Adrenal System / physiopathology
  • Remission Induction

Substances

  • Adrenocorticotropic Hormone
  • Hydrocortisone