Treatment of Cushing's disease remains a challenge. Whereas pituitary surgery can "cure" the patient and restore a completely normal pituitary adrenal axis, there are immediate failures and late recurrences which ultimately require alternate therapeutic approaches. These are numerous, but so are their drawbacks, and all appear to be "default options". For the future, pituitary adenoma has to remain the "reasonable obsession" of efficient and optimistic therapists….
Keywords: Chirurgie surrénalienne; Cushing's disease; Fonction hypophyso-surrénalienne; Maladie de Cushing; Pituitary adrenal axis; Pituitary surgery.
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