Insulin-like growth factor-I (IGF-I) and IGF-I receptor in human testis: an immunohistochemical study

Fertil Steril. 1988 Apr;49(4):666-9. doi: 10.1016/s0015-0282(16)59837-9.


Using specific monoclonal antibodies, the authors studied the distribution of insulin growth factor-I (IGF-I) and its receptor in normal human testis by immunostaining techniques. IGF-I was preferentially localized in Sertoli cells. Less evident positivity was found in primary spermatocytes. In the interstitium some Leydig cells were positive for IGF-I. The major positivity for the IGF-I receptor was found in secondary spermatocytes and early spermatids, whereas Sertoli cells were less positive. An intense positivity was found in some Leydig cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antibodies, Monoclonal
  • Humans
  • Immunoenzyme Techniques
  • Insulin-Like Growth Factor I / analysis*
  • Male
  • Receptor, Insulin / analysis*
  • Receptors, Somatomedin
  • Sertoli Cells / analysis
  • Somatomedins / analysis*
  • Spermatids / analysis
  • Spermatocytes / analysis
  • Testis / analysis*


  • Antibodies, Monoclonal
  • Receptors, Somatomedin
  • Somatomedins
  • Insulin-Like Growth Factor I
  • Receptor, Insulin