Mannose Receptor and the Mystery of Nonhealing Leishmania major Infection

Trends Parasitol. 2018 May;34(5):354-356. doi: 10.1016/j.pt.2018.03.006. Epub 2018 Apr 10.

Abstract

Scientists have long puzzled over the ability of Leishmania major Seidman (LmSd) to form nonhealing cutaneous lesions in the face of a strong Th1 response. A recent study identified a population of dermal macrophages that are preferentially infected by LmSd in a mannose receptor 1-, C-type 1 (MRC1/CD206)-dependent manner.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Humans
  • Interferon-gamma
  • Lectins, C-Type
  • Leishmania major*
  • Leishmaniasis, Cutaneous*
  • Mannose-Binding Lectins
  • Receptors, Cell Surface

Substances

  • Lectins, C-Type
  • Mannose-Binding Lectins
  • Receptors, Cell Surface
  • mannose receptor
  • Interferon-gamma