How much of the missing heritability of ALS is hidden in known ALS genes?

doi:10.1136/jnnp-2018-318354

Editorial

. 2018 Aug;89(8):794.

doi: 10.1136/jnnp-2018-318354. Epub 2018 Apr 12.

How much of the missing heritability of ALS is hidden in known ALS genes?

Philip Van Damme^{1

2

3}

Affiliations

¹ Department of Neuroscience, Experimental Neurology, University of Leuven, Leuven, Belgium.
² VIB, Center for Brain & Disease Research, Laboratory of Neurobiology, Leuven, Belgium.
³ Department of Neurology, University Hospitals Leuven, Leuven, Belgium.

PMID: 29650795
PMCID: PMC6204935
DOI: 10.1136/jnnp-2018-318354

Editorial

How much of the missing heritability of ALS is hidden in known ALS genes?

Philip Van Damme. J Neurol Neurosurg Psychiatry. 2018 Aug.

. 2018 Aug;89(8):794.

doi: 10.1136/jnnp-2018-318354. Epub 2018 Apr 12.

Author

Philip Van Damme^{1

2

3}

Affiliations

¹ Department of Neuroscience, Experimental Neurology, University of Leuven, Leuven, Belgium.
² VIB, Center for Brain & Disease Research, Laboratory of Neurobiology, Leuven, Belgium.
³ Department of Neurology, University Hospitals Leuven, Leuven, Belgium.

PMID: 29650795
PMCID: PMC6204935
DOI: 10.1136/jnnp-2018-318354

No abstract available

Keywords: Als; genetics.

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Conflict of interest statement

Competing interests: None declared.

Comment on

Comprehensive analysis of the mutation spectrum in 301 German ALS families.
Müller K, Brenner D, Weydt P, Meyer T, Grehl T, Petri S, Grosskreutz J, Schuster J, Volk AE, Borck G, Kubisch C, Klopstock T, Zeller D, Jablonka S, Sendtner M, Klebe S, Knehr A, Günther K, Weis J, Claeys KG, Schrank B, Sperfeld AD, Hübers A, Otto M, Dorst J, Meitinger T, Strom TM, Andersen PM, Ludolph AC, Weishaupt JH; German ALS network MND-NET. Müller K, et al. J Neurol Neurosurg Psychiatry. 2018 Aug;89(8):817-827. doi: 10.1136/jnnp-2017-317611. Epub 2018 Apr 12. J Neurol Neurosurg Psychiatry. 2018. PMID: 29650794

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References

1. Hardiman O, Al-Chalabi A, Chio A, et al. . Amyotrophic lateral sclerosis. Nat Rev Dis Primers 2017;3:17085 10.1038/nrdp.2017.85 - DOI - PubMed
1. Al-Chalabi A, Fang F, Hanby MF, et al. . An estimate of amyotrophic lateral sclerosis heritability using twin data. J Neurol Neurosurg Psychiatry 2010;81:1324–6. 10.1136/jnnp.2010.207464 - DOI - PMC - PubMed
1. Müller K, Brenner D, Weydt P, et al. . German ALS network MND-NET. Comprehensive analysis of the mutation spectrum in 301 German ALS families. J Neurol Neurosurg Psychiatry 2018;89:817–27. 10.1136/jnnp-2017-317611 - DOI - PubMed
1. van Blitterswijk M, van Es MA, Hennekam EA, et al. . Evidence for an oligogenic basis of amyotrophic lateral sclerosis. Hum Mol Genet 2012;21:3776–84. 10.1093/hmg/dds199 - DOI - PubMed
1. Morgan S, Shatunov A, Sproviero W, et al. . A comprehensive analysis of rare genetic variation in amyotrophic lateral sclerosis in the UK. Brain 2017;140:1611–8. 10.1093/brain/awx082 - DOI - PMC - PubMed

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[1] Hardiman O, Al-Chalabi A, Chio A, et al. . Amyotrophic lateral sclerosis. Nat Rev Dis Primers 2017;3:17085 10.1038/nrdp.2017.85 - DOI - PubMed

[2] Hardiman O, Al-Chalabi A, Chio A, et al. . Amyotrophic lateral sclerosis. Nat Rev Dis Primers 2017;3:17085 10.1038/nrdp.2017.85 - DOI - PubMed

[3] Al-Chalabi A, Fang F, Hanby MF, et al. . An estimate of amyotrophic lateral sclerosis heritability using twin data. J Neurol Neurosurg Psychiatry 2010;81:1324–6. 10.1136/jnnp.2010.207464 - DOI - PMC - PubMed

[4] Al-Chalabi A, Fang F, Hanby MF, et al. . An estimate of amyotrophic lateral sclerosis heritability using twin data. J Neurol Neurosurg Psychiatry 2010;81:1324–6. 10.1136/jnnp.2010.207464 - DOI - PMC - PubMed

[5] Müller K, Brenner D, Weydt P, et al. . German ALS network MND-NET. Comprehensive analysis of the mutation spectrum in 301 German ALS families. J Neurol Neurosurg Psychiatry 2018;89:817–27. 10.1136/jnnp-2017-317611 - DOI - PubMed

[6] Müller K, Brenner D, Weydt P, et al. . German ALS network MND-NET. Comprehensive analysis of the mutation spectrum in 301 German ALS families. J Neurol Neurosurg Psychiatry 2018;89:817–27. 10.1136/jnnp-2017-317611 - DOI - PubMed

[7] van Blitterswijk M, van Es MA, Hennekam EA, et al. . Evidence for an oligogenic basis of amyotrophic lateral sclerosis. Hum Mol Genet 2012;21:3776–84. 10.1093/hmg/dds199 - DOI - PubMed

[8] van Blitterswijk M, van Es MA, Hennekam EA, et al. . Evidence for an oligogenic basis of amyotrophic lateral sclerosis. Hum Mol Genet 2012;21:3776–84. 10.1093/hmg/dds199 - DOI - PubMed

[9] Morgan S, Shatunov A, Sproviero W, et al. . A comprehensive analysis of rare genetic variation in amyotrophic lateral sclerosis in the UK. Brain 2017;140:1611–8. 10.1093/brain/awx082 - DOI - PMC - PubMed

[10] Morgan S, Shatunov A, Sproviero W, et al. . A comprehensive analysis of rare genetic variation in amyotrophic lateral sclerosis in the UK. Brain 2017;140:1611–8. 10.1093/brain/awx082 - DOI - PMC - PubMed

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How much of the missing heritability of ALS is hidden in known ALS genes?

Affiliations

How much of the missing heritability of ALS is hidden in known ALS genes?

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