The 2H4 (CD45R) antigen is selectively decreased in multiple sclerosis lesions

J Immunol. 1988 Apr 1;140(7):2210-4.


To analyze expression of the 2H4 (CD45R) Ag on inflammatory cells in the central nervous system immune response, immunohistochemical staining with a panel of anti-T cell mAb was performed on central nervous system tissues from 12 patients with multiple sclerosis (MS) and 8 patients with viral encephalitis. Only rare cells were stained with anti-2H4 in MS plaques, plaque edges, and adjacent white matter, whereas 2H4+ cells were more numerous in viral encephalitis (p less than 0.001). By contrast, no quantitative differences were found between MS plaque edges and viral encephalitis with anti-4B4 (helper-inducer function associated), anti-CD4, anti-CD3, and anti-IL-2R mAb, although there were fewer CD8+ cells in MS (p less than 0.01). These data indicate that the 2H4 Ag is selectively decreased and, because it is associated with suppressor-inducer function of CD4+ cells, that there may be a defect in the down-regulation of the in situ immune response in MS.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Acute Disease
  • Adult
  • Antigens, Differentiation / analysis*
  • Antigens, Differentiation, T-Lymphocyte / analysis*
  • Brain / immunology
  • Brain / pathology
  • Chronic Disease
  • Encephalitis / immunology
  • Encephalitis / pathology
  • Herpes Simplex / immunology
  • Herpes Simplex / pathology
  • Humans
  • Leukocyte Common Antigens
  • Multiple Sclerosis / immunology
  • Multiple Sclerosis / pathology*
  • T-Lymphocytes / immunology
  • T-Lymphocytes / pathology*


  • Antigens, Differentiation
  • Antigens, Differentiation, T-Lymphocyte
  • Leukocyte Common Antigens