Individualization of levodopa treatment using a microtablet dispenser and ambulatory accelerometry

CNS Neurosci Ther. 2018 May;24(5):439-447. doi: 10.1111/cns.12807. Epub 2018 Jan 25.


Aim: This 4-week open-label observational study describes the effect of introducing a microtablet dose dispenser and adjusting doses based on objective free-living motor symptom monitoring in individuals with Parkinson's disease (PD).

Methods: Twenty-eight outpatients with PD on stable levodopa treatment with dose intervals of ≤4 hour had their daytime doses of levodopa replaced with levodopa/carbidopa microtablets, 5/1.25 mg (LC-5) delivered from a dose dispenser device with programmable reminders. After 2 weeks, doses were adjusted based on ambulatory accelerometry and clinical monitoring.

Results: Twenty-four participants completed the study per protocol. The daily levodopa dose was increased by 15% (112 mg, P < 0.001) from period 1 to 2, and the dose interval was reduced by 12% (22 minutes, P = 0.003). The treatment adherence to LC-5 was high in both periods. The MDS-UPDRS parts II and III, disease-specific quality of life (PDQ-8), wearing-off symptoms (WOQ-19), and nonmotor symptoms (NMS Quest) improved after dose titration, but the generic quality-of-life measure EQ-5D-5L did not. Blinded expert evaluation of accelerometry results demonstrated improvement in 60% of subjects and worsening in 25%.

Conclusions: The introduction of a levodopa microtablet dispenser and accelerometry aided dose adjustments improve PD symptoms and quality of life in the short term.

Keywords: Parkinson's disease; accelerometry; dose titration; microtablets; observational study.

Publication types

  • Observational Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Accelerometry* / methods
  • Aged
  • Aged, 80 and over
  • Antiparkinson Agents / administration & dosage*
  • Antiparkinson Agents / adverse effects
  • Carbidopa / administration & dosage*
  • Carbidopa / adverse effects
  • Drug Combinations
  • Female
  • Humans
  • Levodopa / administration & dosage*
  • Levodopa / adverse effects
  • Longitudinal Studies
  • Male
  • Medication Adherence
  • Middle Aged
  • Parkinson Disease / drug therapy*
  • Parkinson Disease / physiopathology
  • Precision Medicine / methods*
  • Quality of Life
  • Single-Blind Method
  • Tablets / administration & dosage
  • Treatment Outcome


  • Antiparkinson Agents
  • Drug Combinations
  • Tablets
  • carbidopa, levodopa drug combination
  • Levodopa
  • Carbidopa