Potential Roles of Vascular Endothelial Growth Factor During Skeletal Muscle Hypertrophy

Exerc Sport Sci Rev. 2018 Jul;46(3):195-202. doi: 10.1249/JES.0000000000000152.


Vascular endothelial growth factor (VEGF) deletion in adult mouse muscle fibers contributes to impaired contractile and muscular adaptations to a hypertrophic stimulus suggesting a critical role in adult muscle growth. This review explores the hypothesis that VEGF is essential for adult muscle growth by impacting inflammatory processes, satellite-endothelial cell interactions, and contractile protein accumulation by functioning within known hypertrophic signaling pathways including insulin-like growth factor-1 (IGF-1-Akt) and Wnt-ß-catenin.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Endothelial Cells / cytology
  • Hypertrophy
  • Inflammation
  • Insulin-Like Growth Factor I / physiology
  • Macrophages / cytology
  • Mice
  • Muscle Strength
  • Muscle, Skeletal / growth & development*
  • Proto-Oncogene Proteins c-akt / physiology
  • Satellite Cells, Skeletal Muscle / cytology
  • Vascular Endothelial Growth Factor A / physiology*
  • Wnt Signaling Pathway


  • Vascular Endothelial Growth Factor A
  • vascular endothelial growth factor A, mouse
  • Insulin-Like Growth Factor I
  • Proto-Oncogene Proteins c-akt