Predictors for profound blood pressure response in patients undergoing renal sympathetic denervation

J Hypertens. 2018 Jul;36(7):1578-1584. doi: 10.1097/HJH.0000000000001739.


Background: Renal sympathetic denervation (RDN) as treatment for hypertension shows highly variable results. Although some patients do not show any blood pressure (BP) change and in most patients a BP reduction of at least 5 mmHg can be found, some show a reduction at least 20 mmHg. We sought to identify predictors for such a profound BP response.

Methods: Profound BP response was defined as drop of at least 20 mmHg in daytime systolic ambulatory BP measurement (ABPM) 3 months after catheter-based RDN. Three different denervation devices were used for RDN, and pulse wave velocity was determined invasively in a subgroup of patients.

Results: One hundred and ninety consecutive patients were included in this analysis. Profound BP response was found in 33 patients. Patients with profound BP response were younger (P = 0.04), presented with higher baseline ABPM values (P < 0.001), were treated with ultrasound-based RDN and received more often a combined treatment with two different diuretics (P = 0.005 for both). After 3 months, a treatment target of daytime BP less than 135 mmHg could be achieved more frequently in patients with profound BP response (61 vs. 17%, P < 0.001). Age, use of ultrasound RDN, combined diuretic therapy and baseline BP independently predicted pronounced BP reduction. A second multivariate logistic regression model including pulse wave velocity if available identified baseline BP, pulse wave velocity and use of ultrasound denervation as independent predictors for profound BP response.

Conclusion: Younger vascular age, higher baseline BP, treatment with ultrasound RDN and combined diuretic therapy were found as predictors for a pronounced BP reduction following RDN, improving BP control at follow-up.

MeSH terms

  • Age Factors
  • Aged
  • Blood Pressure*
  • Diuretics / therapeutic use
  • Drug Therapy, Combination
  • Female
  • Humans
  • Hypertension / drug therapy
  • Hypertension / physiopathology
  • Hypertension / surgery*
  • Male
  • Middle Aged
  • Pulse Wave Analysis
  • Renal Artery / innervation*
  • Sympathectomy / methods*
  • Ultrasonic Surgical Procedures*


  • Diuretics