Age-related defects in short-term plasticity are reversed by acetyl-L-carnitine at the mouse calyx of Held

Neurobiol Aging. 2018 Jul;67:108-119. doi: 10.1016/j.neurobiolaging.2018.03.015. Epub 2018 Mar 21.

Abstract

Hearing acuity and sound localization are affected by aging and may contribute to cognitive dementias. Although loss of sensorineural conduction is well documented to occur with age, little is known regarding short-term synaptic plasticity in central auditory nuclei. Age-related changes in synaptic transmission properties were evaluated at the mouse calyx of Held, a sign-inverting relay synapse in the circuit for sound localization, in juvenile adults (1 month old) and late middle-aged (18-21 months old) mice. Synaptic timing and short-term plasticity were severely disrupted in older mice. Surprisingly, acetyl-l-carnitine (ALCAR), an anti-inflammatory agent that facilitates mitochondrial function, fully reversed synaptic transmission delays and defects in short-term plasticity in aged mice to reflect transmission similar to that seen in juvenile adults. These findings support ALCAR supplementation as an adjuvant to improve short-term plasticity and potentially central nervous system performance in animals compromised by age and/or neurodegenerative disease.

Keywords: Acetyl-l-carnitine; Aging; Calyx of held; Electrophysiology; Neurotransmission; Synaptic plasticity.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Acetylcarnitine / pharmacology*
  • Acetylcarnitine / therapeutic use
  • Aging*
  • Animals
  • Anti-Inflammatory Agents / pharmacology*
  • Anti-Inflammatory Agents / therapeutic use
  • Auditory Pathways / drug effects*
  • Auditory Perception / drug effects
  • Auditory Perception / physiology
  • Female
  • Hearing / physiology
  • Hearing Loss, Sensorineural / drug therapy
  • Hearing Loss, Sensorineural / physiopathology
  • Hearing Loss, Sensorineural / psychology
  • Male
  • Mice, Inbred C57BL
  • Neurodegenerative Diseases / drug therapy
  • Neurodegenerative Diseases / physiopathology
  • Neurodegenerative Diseases / psychology
  • Neuronal Plasticity / drug effects*
  • Synapses / physiology*
  • Synaptic Transmission / drug effects*
  • Synaptic Transmission / physiology

Substances

  • Anti-Inflammatory Agents
  • Acetylcarnitine