Chromogranin-A and its derived peptides and their pharmacological effects during intestinal inflammation

Nour Eissa; Hayam Hussein; Geoffrey N Hendy; Charles N Bernstein; Jean-Eric Ghia

doi:10.1016/j.bcp.2018.04.009

Chromogranin-A and its derived peptides and their pharmacological effects during intestinal inflammation

Biochem Pharmacol. 2018 Jun:152:315-326. doi: 10.1016/j.bcp.2018.04.009. Epub 2018 Apr 13.

Authors

Nour Eissa¹, Hayam Hussein², Geoffrey N Hendy³, Charles N Bernstein⁴, Jean-Eric Ghia⁵

Affiliations

¹ Department of Immunology, College of Medicine, University of Manitoba, Winnipeg, MB, Canada; Children's Hospital Research Institute of Manitoba, University of Manitoba, Winnipeg, MB, Canada; IBD Clinical and Research Centre, University of Manitoba, Winnipeg, MB, Canada.
² Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Ohio State University, Columbus, OH, USA.
³ Metabolic Disorders and Complications, McGill University Health Centre-Research Institute, Departments of Medicine, Physiology, and Human Genetics, McGill University, Montréal, QC, Canada.
⁴ IBD Clinical and Research Centre, University of Manitoba, Winnipeg, MB, Canada; Section of Gastroenterology, Department of Internal Medicine, College of Medicine, University of Manitoba, Winnipeg, MB, Canada.
⁵ Department of Immunology, College of Medicine, University of Manitoba, Winnipeg, MB, Canada; Children's Hospital Research Institute of Manitoba, University of Manitoba, Winnipeg, MB, Canada; IBD Clinical and Research Centre, University of Manitoba, Winnipeg, MB, Canada; Section of Gastroenterology, Department of Internal Medicine, College of Medicine, University of Manitoba, Winnipeg, MB, Canada. Electronic address: Jean-Eric.Ghia@umanitoba.ca.

PMID: 29656116
DOI: 10.1016/j.bcp.2018.04.009

Abstract

The gastrointestinal tract is the largest endocrine organ that produces a broad range of active peptides. Mucosal changes during inflammation alter the distribution and products of enteroendocrine cells (EECs) that play a role in immune activation and regulation of gut homeostasis by mediating communication between the nervous, endocrine and immune systems. Patients with inflammatory bowel disease (IBD) typically have altered expression of chromogranin (CHG)-A (CHGA), a major soluble protein secreted by EECs that functions as a pro-hormone. CHGA gives rise to several bioactive peptides that have direct or indirect effects on intestinal inflammation. In IBD, CHGA and its derived peptides are correlated with the disease activity. In this review we describe the potential immunomodulatory roles of CHGA and its derived peptides and their clinical relevance during the progression of intestinal inflammation. Targeting CHGA and its derived peptides could be of benefit for the diagnosis and clinical management of IBD patients.

Keywords: Chromogranin-A derived peptides; Chromogranins; Colitis; Gut hormones; Mucosal drug action.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Chromogranin A / pharmacology*
Humans
Inflammation / drug therapy*
Intestinal Diseases / drug therapy*

Substances

Chromogranin A

Grants and funding

CIHR/Canada