The Role of Adenosine Receptor Activation in Attenuating Cartilaginous Inflammation

Inflammation. 2018 Aug;41(4):1135-1141. doi: 10.1007/s10753-018-0781-z.


Adenosine receptor activation has been explored as a modulator of the inflammatory process that propagates osteoarthritis. It has been reported that cartilage has enhanced regenerative potential when influenced by adenosine receptor activation. As adenosine's role in maintaining chondrocyte homeostasis at the cellular and molecular levels is explored, successful in vivo applications of adenosine delivery for cartilage repair continue to be reported. This review summarizes the role adenosine receptor ligation plays in chondrocyte homeostasis and regeneration of articular cartilage damaged in osteoarthritis. It also reports on all the modalities reported for delivery of adenosine through in vivo applications.

Keywords: cartilage; chondrocyte; regeneration; tissue engineering.

Publication types

  • Review

MeSH terms

  • Animals
  • Cartilage, Articular / drug effects
  • Humans
  • Inflammation / drug therapy
  • Osteoarthritis / drug therapy
  • Osteoarthritis / pathology
  • Receptors, Purinergic P1 / metabolism
  • Receptors, Purinergic P1 / physiology*
  • Receptors, Purinergic P1 / therapeutic use
  • Regeneration / drug effects


  • Receptors, Purinergic P1