Randomized controlled clinical study assessing two membranes for guided bone regeneration of peri-implant bone defects: 3-year results

Clin Oral Implants Res. 2018 May;29(5):499-507. doi: 10.1111/clr.13147. Epub 2018 Apr 15.


Objectives: To assess two- and three-dimensional changes of the peri-implant tissues as well as clinical, biological, and radiological outcomes of implants having been treated with resorbable or nonresorbable membranes at 3 years.

Materials and methods: Twenty-three patients were re-examined after having received a single-tooth implant in the esthetic zone in conjunction with guided bone regeneration (GBR) using either a resorbable (RES) or a titanium-reinforced nonresorbable membrane (N-RES) and demineralized bovine bone mineral. Volumetric and linear as well as clinical and radiographic measurements were performed at crown insertion (baseline), at 1 year (FU-1) and 3 years (FU-3). Statistics were performed by means of parametric and nonparametric tests.

Results: Minor, but ongoing buccal volume loss was observed in both groups during the 3-year follow-up. A slightly higher volume loss was observed in group RES (-0.22 mm) compared to N-RES (-0.14 mm) at 1 year (FU-1), but aligned at 3 years (FU-3) RES (-0.30 mm) N-RES (-0.32 mm). All changes over time were statistically significantly different within (p < .05), but not between the groups (p > .05). Stable median interproximal bone levels after 3 years (FU-3); 0.26 mm (0.04; 0.36) (RES) and 0.14 mm (0.08; 0.20) (N-RES) and healthy tissues (BOP, PD) were obtained with both membranes.

Conclusions: Both treatment modalities resulted in minor, but ongoing contour changes of the peri-implant tissues. Stable interproximal bone levels and healthy tissues can be obtained with membranes up to 3 years.

Keywords: alveolar ridge augmentation; dental implants; membranes; volume stability; volumetric analysis.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Alveolar Ridge Augmentation / methods*
  • Bone Substitutes / therapeutic use
  • Dental Implantation, Endosseous
  • Dental Implants, Single-Tooth
  • Female
  • Guided Tissue Regeneration, Periodontal / methods*
  • Humans
  • Male
  • Middle Aged


  • Bone Substitutes