Mismating Diagnosis and Protocols

Vet Clin North Am Small Anim Pract. 2018 Jul;48(4):605-615. doi: 10.1016/j.cvsm.2018.02.007. Epub 2018 Apr 12.


Mismating, or termination of pregnancy, is a commonly requested reproductive procedure for bitches and queens. Surgical treatment via ovariohysterectomy is the preferred choice when bitches or queens are not desired for future breeding purposes. Animals that are reproductively valuable can be treated with a variety of drugs to terminate the pregnancy. The choice of specific medical therapy is based on safety, efficacy, availability of the drug, and gestational age of the pregnancy. Currently, there is no US Food and Drug Administration-approved treatment of mismating in North America for dogs or cats.

Keywords: Aglepristone; Misalliance; Mismating; Prolactin inhibitors; Prostaglandin F2α.

Publication types

  • Review

MeSH terms

  • Abortion, Induced / methods
  • Abortion, Induced / veterinary*
  • Animals
  • Cats*
  • Dogs*
  • Female
  • Hysterectomy / veterinary*
  • Ovariectomy / veterinary*
  • Pregnancy
  • United States