Semaphorin3A: A potential therapeutic tool in immune-mediated diseases

Eur J Rheumatol. 2018 Mar;5(1):58-61. doi: 10.5152/eurjrheum.2017.17076. Epub 2017 Dec 7.


The significance of semaphorin3A (sema3A) in regulating immune-mediated inflammation is widely reported. There are multiple mechanisms involved in the process of sema3A-mediated regulation. One of them is the ability of sema3A to maintain a sufficient regulation of both T-cell and B-cell activation. Because it is involved in the pathogenesis of many autoimmune, infectious, and malignant diseases, sema3A turns to be a promising therapeutic tool to be studied and applied in these diseases.

Keywords: Semaphorin 3A; atopic diseases; immune mediated diseases.

Publication types

  • Review