1 From the Department of Anaesthesiology, Medical Faculty of Heinrich-Heine University, Düsseldorf University Hospital, Düsseldorf (TAT), Department of Anaesthesiology and Intensive Care, University Hospital Carl Gustav Carus, Dresden, Germany (MGdA), Department of Surgical Sciences and Integrated Diagnostics, IRCCS San Martino IST, University of Genoa, Genoa, Italy (PP), Laboratory of Experimental Intensive Care and Anaesthesiology (LEICA); and Laboratory of Experimental Intensive Care and Anesthesiology, Department of Intensive Care, Academic Medical Centre, Amsterdam, the Netherlands (MJS).