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. 2018 May 4;20(9):2522-2525.
doi: 10.1021/acs.orglett.8b00599. Epub 2018 Apr 16.

Palladium-Catalyzed Direct C-H Arylation of 3-(Methylsulfinyl)thiophenes

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Palladium-Catalyzed Direct C-H Arylation of 3-(Methylsulfinyl)thiophenes

Hui Jiang et al. Org Lett. .

Abstract

A palladium-catalyzed direct arylation of (3-thiophene)S(O)Me derivatives has been developed. This protocol is effective for the selective synthesis of 2-arylated and 2,5-diarylated sulfinylthiophene derivatives with as low as 0.5 mol % catalyst loading. Various functional groups are well tolerated. A method to install two different aryl groups on 3-(methylsulfinyl)thiophenes is also introduced.

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