Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
, 78 (2), 127-130

[Association Between Central Diabetes Insipidus and Type 2 Diabetes Mellitus]

[Article in Spanish]
  • PMID: 29659364
Case Reports

[Association Between Central Diabetes Insipidus and Type 2 Diabetes Mellitus]

[Article in Spanish]
Claudia Palumbo et al. Medicina (B Aires).


Central diabetes insipidus is a rare disease of the hypothalamus and neurohypophysis. It is very unusually found in the adult with type 2 diabetes mellitus. It is manifested by a polydipsic polyuric syndrome, which must be distinguished from the poorly controlled type 2 diabetes mellitus. Given the similarity of both entities and the unusual nature of their coexistence, their suspicion is difficult. The case of a 72-year-old male with type 2 diabetes mellitus with poor insulin control (fasting hyperglycemia greater than 180 mg/dl) who had a long-standing polyuric syndrome is here presented. Hypernatremia and plasma osmolality elevated together with a low urinary osmolality led to the suspicion of diabetes insipidus, which was subsequently confirmed by the dehydration test and the administration of desmopressin sc. With 61% increase in the calculated urinary osmolarity one hour post desmopressin s.c., diabetes insipidus of central type was diagnosed. Nuclear Magnetic Resonance showed a bright spot with normal neurohypophysis, contributing to the diagnosis of the idiopathic form.

Keywords: central diabetes insipidus; elderly adult; type 2 diabetes mellitus.

Similar articles

See all similar articles

Cited by 2 articles

Publication types

MeSH terms