Aims: To evaluate the prognostic and clinicopathological features of glioma with BRMS1L expression.
Methods: Total 120 glioma samples were obtained as discovery cohort. CGGA, GSE and TCGA datasets were obtained as validation sets. Furthermore, Kaplan-Meier survival and multivariate Cox analysis were used to evaluate the survival distributions. Moreover, the functional role of BRMS1L was also analyzed by transwell assay.
Results: In the discovery cohort, decreased BRMS1L expression was significantly associated with high-grade glioma as well as the higher mortality in survival analysis (log-rank test, p< 0.01). And the three validation cohorts showed the similar results. Furthermore, BRMS1L act as an independent prognostic factor in glioblastoma patients. Additionally, functional assay showed that ectopic of BRMS1L suppressed glioma cells' invasion.
Conclusion: BRMS1L plays as an anti-oncogene in GBM and indicates a new potential therapeutic target.
Keywords: BRMS1L; Glioma; invasion; prognostic.