Malignant lymphoma in the HIV-positive patient

Eur J Haematol. 2018 Jul;101(1):119-126. doi: 10.1111/ejh.13082. Epub 2018 May 22.


The introduction of combination antiretroviral therapy (cART) drastically improved performance status, immune function, and life expectancy of HIV-infected individuals. In addition, incidence of opportunistic infections and of AIDS-defining malignancies declined. Nevertheless, aggressive non-Hodgkin's lymphoma still remains the leading cause of AIDS-related deaths. The availability of cART, however, significantly improved the therapeutic options for HIV-positive patients with lymphomas. Diffuse large B-cell lymphoma, Burkitt's lymphoma, or Hodgkin lymphoma has increasingly become curable diseases. In light of these favorable developments in the treatment of HIV and HIV-associated lymphomas, reduction in treatment-associated toxicities and further improvement of outcome of patients with advanced immune suppression are major requirements for future clinical trials. This review summarizes the current treatment landscape and gives an overview on future needs in HIV-positive patients with lymphoma.

Keywords: HIV; lymphoma; treatment.

Publication types

  • Review

MeSH terms

  • Anti-HIV Agents / therapeutic use*
  • Antineoplastic Agents / therapeutic use
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
  • Antiretroviral Therapy, Highly Active
  • Burkitt Lymphoma / diagnosis
  • Burkitt Lymphoma / drug therapy*
  • Burkitt Lymphoma / mortality
  • Burkitt Lymphoma / virology
  • Drug Administration Schedule
  • Drug Dosage Calculations
  • HIV Infections / diagnosis
  • HIV Infections / drug therapy*
  • HIV Infections / mortality
  • HIV Infections / virology
  • Hodgkin Disease / diagnosis
  • Hodgkin Disease / drug therapy*
  • Hodgkin Disease / mortality
  • Hodgkin Disease / virology
  • Humans
  • Lymphoma, AIDS-Related / diagnosis
  • Lymphoma, AIDS-Related / drug therapy*
  • Lymphoma, AIDS-Related / mortality
  • Lymphoma, AIDS-Related / virology
  • Lymphoma, Large B-Cell, Diffuse / diagnosis
  • Lymphoma, Large B-Cell, Diffuse / drug therapy*
  • Lymphoma, Large B-Cell, Diffuse / mortality
  • Lymphoma, Large B-Cell, Diffuse / virology
  • Survival Analysis
  • Treatment Outcome


  • Anti-HIV Agents
  • Antineoplastic Agents

Associated data

  • GENBANK/NCT01410344
  • GENBANK/NCT01771107