Management of adenovirus infection in patients after haematopoietic stem cell transplantation: State-of-the-art and real-life current approach: A position statement on behalf of the Infectious Diseases Working Party of the European Society of Blood and Marrow Transplantation

Rev Med Virol. 2018 May;28(3):e1980. doi: 10.1002/rmv.1980. Epub 2018 Apr 16.

Abstract

The important insights gained over the past years in diagnosis and treatment of invasive adenoviral infections provide new paradigms for the monitoring and clinical management of these life-threatening complications. A meeting was held to discuss and subsequently disseminate the current advances in our understanding of the aetiology/pathogenesis and future treatment options facilitating effective control or prevention of adenovirus-related diseases in the allogeneic haematopoietic stem cell transplant setting. Invited experts in the field discussed recent progress with leading members of the Infectious Diseases Working Party of the European Society of Blood and Marrow Transplantation at the "State-of-the-art" Meeting in Poznan, Poland, in October 2017. In this review article, the panel of experts presents a concise summary of the current evidence based on published data from the last 15 years and on recent achievements resulting from real-life practice. The present position statement reflects an expert opinion on current approaches to clinical management of adenovirus infections in patients undergoing allogeneic haematopoietic stem cell transplant and provides graded recommendations of the panel for diagnostic approaches and preemptive therapy reflecting the present state of knowledge.

Keywords: HSCT; adenovirus infection; diagnostics; preemptive therapy; stool monitoring.

Publication types

  • Review

MeSH terms

  • Adenoviridae Infections / diagnosis*
  • Adenoviridae Infections / etiology*
  • Adenoviridae Infections / therapy*
  • Antiviral Agents / pharmacology
  • Antiviral Agents / therapeutic use
  • Combined Modality Therapy
  • Disease Management
  • Gastrointestinal Tract / metabolism
  • Gastrointestinal Tract / pathology
  • Gastrointestinal Tract / virology
  • Hematopoietic Stem Cell Transplantation / adverse effects*
  • Humans
  • Immunotherapy
  • Recurrence
  • Risk Factors
  • Treatment Outcome

Substances

  • Antiviral Agents