An evaluation of the antiaging properties of strawberry hydrolysate treatment enriched with L-ascorbic acid applied with microneedle mesotherapy

J Cosmet Dermatol. 2019 Feb;18(1):129-135. doi: 10.1111/jocd.12545. Epub 2018 Apr 16.


Background: Mature skin is characterized by a loss of elasticity, hyperpigmentation, and dehydration. L-ascorbic acid stimulates the synthesis of collagen type I, inhibits melanogenesis, and helps to maintain correct skin hydration. Combining microneedle mesotherapy with the application of preparations rich in vitamin C results in better therapeutic effects due to the improved absorption of active substances. The study evaluates the effectiveness of the application of strawberry hydrolysate enriched with L-ascorbic acid using microneedle mesotherapy.

Materials and methods: Seventeen volunteers aged 45-70 years underwent a series of four microneedle mesotherapy treatments with vitamin C serum, performed every 10 days. The 20% L-ascorbic acid solution (pH = 3.5) was prepared immediately before application. After the treatment, the participants gave a subjective assessment of the effectiveness. Cutometer® was used to measure skin elasticity and firmness, Corneometer® to measure skin hydration, and Mexameter® skin tone.

Results: The results of the survey showed improvements in skin hydration and elasticity. In vivo studies confirmed the effectiveness of serum and the impact of the active substance on skin firmness and elasticity, the degree of hydration and skin tone.

Conclusion: Microneedling with vitamin C improves skin tone, hydratation and firmness, and decreases the visibility of hyperpigmentation.

Keywords: antioxidant; combination therapy; microneedling; skin aging; skin penetration; vitamin C.

MeSH terms

  • Antioxidants / administration & dosage
  • Antioxidants / therapeutic use*
  • Ascorbic Acid / administration & dosage
  • Ascorbic Acid / therapeutic use*
  • Cheek
  • Female
  • Forehead
  • Fragaria*
  • Humans
  • Mesotherapy / methods*
  • Middle Aged
  • Needles
  • Plant Preparations / therapeutic use*
  • Skin Aging / drug effects*
  • Skin Physiological Phenomena / drug effects
  • Surveys and Questionnaires


  • Antioxidants
  • Plant Preparations
  • Ascorbic Acid