Maca polysaccharides: Extraction optimization, structural features and anti-fatigue activities

Int J Biol Macromol. 2018 Aug;115:618-624. doi: 10.1016/j.ijbiomac.2018.04.063. Epub 2018 Apr 14.


The maca polysaccharides optimal extraction conditions were obtained by using response surface methodology (RSM) method and the anti-fatigue activity of maca polysaccharides (MCP) was explored. The maca polysaccharides extract yield of RSM could reach 9.97 mg/g by using the model predicts, and the total sugar and protein purity were 61.00% and 4.46% with the further isolation process, respectively. And the monosaccharide compositions obtained by gas chromatograph (GC) were composed of rhamnose (rha), glucose (glc), galactose (gal) with the ratio of 2.34:10.21:1.00. Furthermore, the anti-fatigue activity was evaluated by the swimming parameter, biochemistry parameters (liver glycogen (LG), blood urea nitrogen (BUN), and lactic acid (LD)), the result indicated that the low-dose maca polysaccharides group had the significant anti-fatigue activity.

Keywords: Anti-fatigue; Maca polysaccharides; Optimization; Structural features.

MeSH terms

  • Animals
  • Body Weight / drug effects
  • Fatigue / drug therapy*
  • Fatigue / metabolism
  • Fatigue / physiopathology
  • Lepidium / chemistry*
  • Male
  • Mice
  • Polysaccharides / chemistry*
  • Polysaccharides / isolation & purification
  • Polysaccharides / pharmacology*
  • Polysaccharides / therapeutic use
  • Swimming


  • Polysaccharides