Oscillatory activity and cortical coherence of the nucleus basalis of Meynert in Parkinson's disease dementia

Muhammad Nazmuddin; D L Marinus Oterdoom; J Marc C van Dijk; Jonathan C van Zijl; Anne K Kampman; Gea Drost; Teus van Laar; Martijn Beudel

doi:10.1016/j.parkreldis.2018.03.024

Oscillatory activity and cortical coherence of the nucleus basalis of Meynert in Parkinson's disease dementia

Parkinsonism Relat Disord. 2018 Jul:52:102-106. doi: 10.1016/j.parkreldis.2018.03.024. Epub 2018 Mar 28.

Authors

Muhammad Nazmuddin¹, D L Marinus Oterdoom², J Marc C van Dijk², Jonathan C van Zijl¹, Anne K Kampman², Gea Drost², Teus van Laar¹, Martijn Beudel³

Affiliations

¹ Department of Neurology, University Medical Center Groningen, Groningen, The Netherlands.
² Department of Neurosurgery, University Medical Center Groningen, Groningen, The Netherlands.
³ Department of Neurology, University Medical Center Groningen, Groningen, The Netherlands; Department of Neurology, Isala Klinieken, Zwolle, The Netherlands. Electronic address: M.Beudel@umcg.nl.

PMID: 29665982
DOI: 10.1016/j.parkreldis.2018.03.024

Abstract

Background: Deep brain stimulation (DBS) of the nucleus basalis of Meynert (NBM) is a new potential treatment for Parkinson's Disease dementia (PDD) and other types of dementia. To get a better understanding of this structure, its local neurophysiological properties and cortical connectivity patterns were studied.

Methods: We simultaneously recorded DBS local field potentials (LFPs) and electroencephalography (EEG) in two patients with PDD. Both patients had DBS electrodes in the internal globus pallidus (GPi) with one or more distal contacts close to or inside the NBM. Measurements were obtained during routine battery replacement. The distance of DBS contacts to the NBM were calculated using CT-MRI fusion.

Results: Delta (1-4 Hz) oscillations were more prominently present in the NBM region than in its vicinity, whereas temporal coherence in the theta (4-8 Hz) range was less outspoken.

Conclusion: These neurophysiological characteristics, if also proven in larger cohorts, might help to map the NBM more precisely during electrode implantation.

Keywords: Nucleus basalis of Meynert; Parkinson's disease dementia.

MeSH terms

Aged
Basal Nucleus of Meynert / physiopathology*
Brain Waves / physiology*
Cortical Synchronization / physiology*
Deep Brain Stimulation
Delta Rhythm / physiology
Dementia / physiopathology*
Female
Globus Pallidus / physiology
Humans
Male
Parkinson Disease / physiopathology*
Theta Rhythm / physiology